I am a specialist in Respiratory Medicine with special interest in Interventional Pulmonary, Allergy-Asthma, Immunology, Tuberculosis, Pleural diseases, Covid and post covid syndromes, Sleep Medicine, critical care and other Respiratory diseases.
Immunology is the study of the immune system and is a very important branch of the medical and biological sciences. The immune system protects us from infection through various lines of defence. If the immune system is not functioning as it should, it can result in disease, such as autoimmunity, allergy and cancer. It is also now becoming clear that immune responses contribute to the development of many common disorders not traditionally viewed as immunologic, including metabolic, cardiovascular, and neurodegenerative conditions such as Alzheimer’s.
The immune system is a complex system of structures and processes that has evolved to protect us from disease. Molecular and cellular components make up the immune system. The function of these components is divided up into nonspecific mechanisms, those which are innate to an organism, and responsive responses, which are adaptive to specific pathogens. Fundamental or classical immunology involves studying the components that make up the innate and adaptive immune system.
Innate immunity is the first line of defence and is non-specific. That is, the responses are the same for all potential pathogens, no matter how different they may be. Innate immunity includes physical barriers (e.g. skin, saliva etc) and cells (e.g. macrophages, neutrophils, basophils, mast cells etc). These components ‘are ready to go’ and protect an organism for the first few days of infection. In some cases, this is enough to clear the pathogen, but in other instances the first defence becomes overwhelmed and a second line of defence kicks in.
Adaptive immunity is the second line of defence which involves building up memory of encountered infections so can mount an enhanced response specific to the pathogen or foreign substance. Adaptive immunity involves antibodies, which generally target foreign pathogens roaming free in the bloodstream. Also involved are T cells, which are directed especially towards pathogens that have colonised cells and can directly kill infected cells or help control the antibody response.
The immune system is a highly regulated and balanced system and when the balance is disturbed, disease can result. Research in this area involves studying disease that is caused by immune system dysfunction. Much of this work has significance in the development of new therapies and treatments that can manage or cure the condition by altering the way the immune system is working or, in the case of vaccines, priming the immune system and boosting the immune reaction to specific pathogens.
Immunodeficiency disorders involve problems with the immune system that impair its ability to mount an appropriate defence. As a result, these are almost always associated with severe infections that persist, recur and/or lead to complications, making these disorders severely debilitating and even fatal. There are two types of immunodeficiency disorders: primary immunodeficiencies are typically present from birth, are generally hereditary and are relatively rare. Such an example is common variable immunodeficiency (CVID). Secondary immunodeficiencies generally develop later in life and may result following an infection, as is the case with AIDS following HIV infection.
Autoimmune diseases occur when the immune system attacks the body it is meant to protect. People suffering from autoimmune diseases have a defect that makes them unable to distinguish 'self' from ‘non-self’ or 'foreign' molecules. The principles of immunology have provided a wide variety of laboratory tests for the detection of autoimmune diseases. Autoimmune diseases may be described as 'primary' autoimmune diseases, like type-1 diabetes, which may be manifested from birth or during early life; or as 'secondary' autoimmune diseases, which manifest later in life due to various factors. Rheumatoid arthritis and multiple sclerosis are thought to belong to this type of autoimmunity. Also, autoimmune diseases can be localised, such as Crohn’s Disease affecting the GI tract, or systemic, such as systemic lupus erythematosus (SLE).
Allergies are hypersensitivity disorders that occur when the body's immune system reacts against harmless foreign substances, resulting in damage to the body's own tissues. Almost any substance can cause allergies (an allergen), but most commonly, allergies arise after eating certain types of food, such as peanuts, or from inhaling airborne substances, such as pollen, or dust. In allergic reactions, the body believes allergens are dangerous and immediately produces substances to attack them. This causes cells of the immune system to release potent chemicals like histamine, which causes inflammation and many of the symptoms associated with allergies. Immunology strives to understand what happens to the body during an allergic response and the factors responsible for causing them. This should lead to better methods of diagnosing, preventing and controlling allergic diseases.
